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In many cases, providers may instead recommend selecting the peptide that best aligns with the patients primary goals

It is important to underscore the fact that pioglitazone is associated with potentially serious adverse events such as fluid retention, weight gain, and increased risk of congestive heart failure, albeit in the absence of increased cardiovascular mortality [62, 63]

My take: GLP-1RAs may become more than metabolic drugs, but oncology needs prospective cancer-outcome data before calling this prevention